PRediction of DIverse Glucocorticoids ToxIcity OUtcomeS
University Hospital, Brest
300 participants
Mar 18, 2021
OBSERVATIONAL
Conditions
Summary
To date, there is no available tool that allows, at individual level, determination of the probability to develop clinically relevant complications of prolonged glucocorticoid therapy. In patients with inflammatory rheumatic disorders requiring prolonged glucocorticoid therapy, such tool could be useful to adapt first-line treatment decisions (in daily practice and in future clinical trials). The main objective of the study is to identify routine clinical, biological and DXA baseline characteristics predictive of the occurrence of clinically relevant complications of glucocorticoid therapy at 1 year, in order to propose a predictive score.
Eligibility
Inclusion Criteria4
- Life expectancy > 1 year.
- Indication to initiate prolonged glucocorticoid therapy at a dosage ≥ 15 mg/day for the treatment of an inflammatory rheumatic disease.
- Initial treatment or relapse.
- Previsional treatment duration > 3 months.
Exclusion Criteria2
- Unable to consent.
- Previous corticosteroid therapy in the last 3 months at a significant dosage (> 5 mg per day).
Interested in this trial?
Get notified about updates and connect with the research team.
Locations(11)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04664465