RecruitingNot ApplicableNCT04664933
Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With Endovascular Therapy (INSIST-ET)
Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With Endovascular Therapy (INSIST-ET): One Single Center, Safety and Feasibility Study
Sponsor
Hui-Sheng Chen
Enrollment
30 participants
Start Date
Dec 1, 2020
Study Type
INTERVENTIONAL
Conditions
Summary
To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who received recanalization operation.
Eligibility
Min Age: 18 Years
Inclusion Criteria3
- Age ≥18 years;
- Acute ischemic stroke patients who is eligible for endovascular treatment;
- Signed informed consent.
Exclusion Criteria5
- Modified Rankin Score >2 caused by a history of prior stroke;
- Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia (<80000/mm3);
- Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis;
- Severe hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg);
- Unsuitable for this clinical studies assessed by researcher.
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Interventions
DRUGIntra-arterial administration of neuroprotective agents
Intra-arterial administration of 3-n-butylphthalide for 16 to 24 hours during and after the operation at 17.36 to 26.04 ug/min
Locations(1)
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NCT04664933
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