RecruitingNot ApplicableNCT04664933

Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With Endovascular Therapy (INSIST-ET)

Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With Endovascular Therapy (INSIST-ET): One Single Center, Safety and Feasibility Study

Sponsor

Hui-Sheng Chen

Enrollment

30 participants

Start Date

Dec 1, 2020

Study Type

INTERVENTIONAL

Conditions

Stroke, Ischemic Mechanical Thrombectomy Intravascular Thrombosis

Summary

To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who received recanalization operation.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Age ≥18 years;
Acute ischemic stroke patients who is eligible for endovascular treatment;
Signed informed consent.

Exclusion Criteria5

Modified Rankin Score \>2 caused by a history of prior stroke;
Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia (\<80000/mm3);
Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis;
Severe hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg);
Unsuitable for this clinical studies assessed by researcher.

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Interventions

DRUGIntra-arterial administration of neuroprotective agents

Intra-arterial administration of 3-n-butylphthalide for 16 to 24 hours during and after the operation at 17.36 to 26.04 ug/min

Locations(1)

Department of Neurology, General Hospital of Northern Theater Command

Shenyang, China

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