RecruitingNCT04665388

LANDscape MApping of Epitopes and T Cell Receptors for Selected Cancers


Sponsor

University Health Network, Toronto

Enrollment

105 participants

Start Date

Nov 30, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

This is a correlative research project aimed at characterizing the T cell mediated immune responses to hepatocellular carcinoma (HCC), as well as Epstein-Barr virus (EBV)- and human papillomavirus (HPV)-related cancers. This study will enroll approximately 105 patients over 48 months. Of these 105 patients, 30 are EBV-related cancer, 45 are HPV-related cancer, and 30 are HCC. Patients will have blood samples collected one time to identify cancer specific T cells and T cell receptors in their blood. They will also have tissue samples collected one time to study the different types of immune cells, especially the T cells and their receptors. The 105 patients enrolled in this study will be compared to retrospective samples (N=210; 30 from EBV-related cancer cohort, 180 from HPV-related cancer cohort).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is mapping the immune response in patients with certain virus-related cancers — including those linked to HPV (such as head and neck, cervical, and anal cancers) and EBV (such as nasopharyngeal cancer), as well as liver cancer. Researchers are collecting blood and tissue samples to better understand how the immune system sees and responds to these cancers, which could help develop better vaccines and treatments. **You may be eligible if you:** - Have been diagnosed with an HPV-related cancer (head and neck, cervix, vulva, or anal canal), an EBV-related cancer (such as nasopharyngeal cancer), or hepatocellular carcinoma (liver cancer) - Are able to provide tissue samples for analysis **You may NOT be eligible if you:** - Do not have one of the specific cancer types this study is targeting - Cannot provide adequate tissue or blood samples Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.


Locations(1)

Princess Margaret Cancer Centre

Toronto, Ontario, Canada

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT04665388


Related Trials