OPTIMIzation of Treatment SElection and Follow up in Oligometastatic Colorectal Cancer

This study is looking at the best way to monitor and treat people with colorectal cancer (bowel cancer) that has spread to a limited number of other spots in the body — called "oligometastatic" disease. After local treatments like surgery or radiation wipe out those spots, researchers want to know if chemotherapy afterward helps prevent the cancer from coming back. **You may be eligible if...** - You are 18 or older - You have colorectal cancer that spread to a limited number of sites and those sites were treated with surgery, ablation, or radiation - Scans show no remaining signs of cancer after treatment - Your blood counts, liver, and kidney function are in an acceptable range - You are physically able to handle combination chemotherapy (performance status 0–2) **You may NOT be eligible if...** - Scans show cancer has spread further - You are too frail or have too many other health problems for intensive chemotherapy - You have significant nerve damage (neuropathy) - You had another cancer in the last 5 years (except certain skin cancers) - You are pregnant or breastfeeding - You have known allergies to the study chemotherapy drugs Talk to your doctor to see if this trial is right for you.