RecruitingNCT04690660

Swiss Postpartum Hypertension Cohort

Swiss Postpartum Hypertension Cohort (Swiss-PPHT)

Sponsor

University Hospital, Basel, Switzerland

Enrollment

480 participants

Start Date

Jun 4, 2020

Study Type

OBSERVATIONAL

Conditions

Postpartum Hypertension (PPHT)

Summary

This open label, prospective observational, single-center registry is to study short-, intermediate-and long-term course of postpartum hypertension and predictors/risk factors associated with long term cardiovascular and renal risk. Current disease management strategies will be evaluated.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a registry study in Switzerland collecting data on women who develop high blood pressure during or after pregnancy (a condition called postpartum or gestational hypertension), to better understand how to manage and monitor this condition long-term. **You may be eligible if...** - You are a woman who developed high blood pressure during pregnancy (gestational hypertension or preeclampsia) - You have high blood pressure after delivery (within 14 days of birth: systolic ≥ 140 or diastolic ≥ 90 mmHg) - You had pre-existing high blood pressure before pregnancy, or were on blood pressure medication **You may NOT be eligible if...** - Your delivery was more than 14 days ago - You are unable to give consent due to language barriers or lack of understanding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERData collection for parameters of organ damage (cardiac and renal blood markers)

Blood results will be taken out of next routine venipuncture. Routinely collected standard parameters are a blood count, chemistry panel including renal parameters and electrolytes, lipid profile and a HbA1c as well as albumin/creatinine and protein/creatinine ratio in urine.

OTHERData collection for blood pressure (BP)

Clinic blood pressure and 24hour BP Measurements

OTHERHome-based blood pressure management (substudy)

Subjects participating in home-based blood pressure management via telemonitoring will receive a free HekaHealth application (App) for the structured assessment of HBPM.

OTHERBiomarker Profiles (substudy)

Substudy where possible cardiac, renal and pregnancy related biomarkers will be additionally analyzed. The following biomarkers will be analyzed: N terminal (NT)-proBNP, Troponin, elevated mid-regional pro-atrial natriuretic peptide (ANP), elevated mid-regional pro adrenomedullin (ADM), soluble fms-like tyrosine kinase (sFlt-1), and placenta growth factor (PlGF).

OTHERData collection on patient reported outcomes

Data collection on patient reported outcomes (Questionnaire EQ-5D, Questionnaire for App based monitoring )

Locations(1)

Medical Outpatient Department and Hypertension Clinic, University Hospital Basel

Basel, Switzerland

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NCT04690660