Anticoagulant Plus Antiplatelet Therapy Following Iliac Vein Stenting

This trial studies the best way to prevent blood clots from forming in vein stents placed in the pelvis after a deep vein thrombosis (DVT). When a large clot blocks the iliac (pelvic) vein, doctors often clear it with a procedure and then place a stent to keep the vein open. After stenting, blood-thinning medication (anticoagulants) alone is the usual treatment — but some doctors also add antiplatelet drugs (like those used after heart stents) to help prevent clots. This study compares these two approaches. The trial is open to adults 18 and older who were recently diagnosed with an acute DVT involving the iliac vein, had a mechanical clot removal procedure, and received a vein stent within 30 days of that procedure. You may be eligible if: - You are 18 or older - You were diagnosed with an acute DVT (onset within 3 weeks) in your pelvic/iliac vein - You underwent a mechanical clot removal procedure (with or without clot-dissolving infusion) - A vein stent was placed in your iliac vein during or within 30 days of the procedure You may NOT be eligible if: - Your DVT is chronic (more than 3 weeks old) - Your DVT only involves veins below the thigh (no iliac involvement) - Your kidney function is significantly reduced (GFR below 60 mL/min) - You have pre-existing varicose veins or venous insufficiency in that leg - You have serious artery disease, aneurysms, or arterial problems in the same region - You are already taking anticoagulants or antiplatelets for another condition - You had a heart attack in the past 6 months or are at high bleeding risk Talk to your doctor to see if this trial is right for you.