RecruitingPhase 2NCT04695782
Pencil Beam Proton Therapy for Pelvic Recurrences in Rectal Cancer Patients Previously Treated With Radiotherapy
Sponsor
University of Aarhus
Enrollment
65 participants
Start Date
Oct 10, 2020
Study Type
INTERVENTIONAL
Conditions
Summary
Study design: A prospective phase II, non-randomized observational study of dose-escalated pencil beam proton therapy re-irradiation for pelvic recurrences from rectal cancer. Re-irradiation is either a part of neo-adjuvant treatment or as a definitive treatment strategy for un-resectable recurrences.
Eligibility
Min Age: 18 Years
Inclusion Criteria9
- Locally recurrent rectal cancer.
- Bioptically verified (adenocarcinoma )
- Available dose plan from primary radiotherapy
- Previous pelvic RT (>30Gy EQD2)
- Evaluated in MDT-conferences (Herlev, Aarhus)
- Age>18 years
- PS 0-2
- Adequate organ function
- Informed consent
Exclusion Criteria3
- Non-resectable distant metastases (PET-CT)
- Unable to undergo MRI, PET-CT
- Inability to attend full course radiotherapy and follow up in the out patient clinic.
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Interventions
RADIATIONPencil beam proton radiotherapy
Doseescalated pencil beam proton Therapy
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04695782