Protective Effect of Statin Against Negative Cardiovascular Remodeling and Organ Dysfunction After Acute Aortic Syndrome Surgery (PANDA III)
Nanjing Medical University
300 participants
Jan 1, 2021
INTERVENTIONAL
Conditions
Summary
Acute Aortic Syndrome (AAS)/Aortic Aneurysm is a common feature of aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year between the ages of 65 and 75 years. Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, the authors hypothesized that people with acute aortic syndrome but without hyperlipidemia might benefit from statin treatment.
Eligibility
Inclusion Criteria4
- (1) Patients with aortic dissection/ulceration/intermural hematoma/aortic aneurysm who underwent aortic arch replacement or endoluminal isolation or hybrid therapy;
- (2) Paitents without clinically significant hyperlipidemia but with cardiovascular disease risk factors (such as male ≥45 years old, female ≥55 years old, hypertension, diabetes, chronic kidney disease, obesity, low HDL cholesterol, smoking, alcohol consumption, family history of early onset ischemic cardiovascular disease) and no previous use of statins;
- (3) Patients are between 18 and 85 years old, male or female;
- (4) Agree to participate in the study and sign the informed consent.
Exclusion Criteria6
- (1) Patients with allergy to statins;
- (2) patients with active liver disease;
- (3) patients with myopathy;
- (4) Lactating women and pregnant women;
- (5) Patients with mental diseases, drug and alcohol dependence;
- (6) Refuse to participate in the study or sign the informed consent.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Rosuvastatin 10mg is taken by oral or nasal feeding every day at ang time.
Locations(5)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04699279