RecruitingNCT04701671

Project THINK: Trajectories of Health, Ingestive Behaviors, and Neurocognition in Kids

Executive Functioning, Weight Trajectories, and Loss of Control Eating in Children With Overweight/Obesity: A Prospective Study


Sponsor

University of Pittsburgh

Enrollment

180 participants

Start Date

Dec 10, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

Overweight/obesity and loss of control eating (characterized by the sense that one cannot control what or how much one is eating) are prevalent among children and adolescents, and both are associated with serious medical and psychosocial health complications. Although our recently published data suggest that youth with these conditions may have relative deficits in neurocognitive functioning, particularly working memory, understanding of how these processes and their neural correlates are related to change and stability in eating and weight-related outcomes over time is limited, thereby impeding development of targeted, optimally timed interventions. The present study aims to assess prospective associations between general and food-specific executive functioning and underlying neural substrates, and eating and weight outcomes among children at varying levels of risk overweight/obesity and eating disorders, which will help guide research efforts towards the development of effective prevention and intervention strategies.


Eligibility

Min Age: 9 YearsMax Age: 12 Years

Plain Language Summary

Simplified for easier understanding

Project THINK is a long-term observational study examining how brain-based differences in self-control — particularly working memory and the ability to resist food cues — relate to weight gain and loss-of-control eating in children and adolescents over time. Using brain imaging and cognitive tests, researchers aim to understand which children are most at risk and when is the best time to intervene. Children at varying levels of risk for overweight and eating disorders are eligible, provided they are not taking medications that affect weight, do not have conditions that impair cognitive function, and are fluent in English. Participation involves brain MRI scans, computer-based cognitive tasks, and assessments of eating behavior and weight over an 18-month period. This summary was prepared to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALObservational (not including MRI scanning)

Observational data will be obtained through self-report measures, parental report measures, cognitive assessments, and a semi-structured interview.

BEHAVIORALObservational (including MRI scanning)

Observational data will be obtained through self-report measures, parental report measures, cognitive assessments, fMRI imaging, and a semi-structured interview.


Locations(2)

University of PIttsburgh

Pittsburgh, Pennsylvania, United States

Weight Control & Diabetes Research Center

Providence, Rhode Island, United States

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NCT04701671


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