SHAPE of Portal Hypertension in Children

This study uses a specialized ultrasound with a contrast agent to measure blood pressure in the portal vein (a major vein carrying blood to the liver) in children with liver disease. High pressure in this vein — called portal hypertension — is a serious complication of chronic liver disease. **You may be eligible if:** - You are a child with chronic liver disease, with or without portal hypertension **You may NOT be eligible if:** - You are pregnant - You have a known allergy to eggs or egg-based products (the contrast agent contains egg components) - You have had a prior liver transplant - You have cystic fibrosis, chronic lung disease, or significant heart disease - You have a clot or blockage in the portal vein - You have a syndrome involving missing or extra spleens (asplenia/polysplenia) with biliary atresia Talk to your doctor to see if this trial is right for you.