RecruitingNCT04721899

Vitamin D and Endometrial Receptivity in Infertile Women

Effect of Vitamin D on Vaginal / Endometrial Biomarkers and Endometrial Receptivity in Women With Fertility Problems

Sponsor

The University of Hong Kong

Enrollment

105 participants

Start Date

Jan 15, 2021

Study Type

OBSERVATIONAL

Conditions

Infertility

Summary

This is a prospective study comparing vaginal and endometrial biomarkers and the trophoblast spheroid attachment rate in women with fertility problems before and after taking Vitamin D for 8 weeks.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 40 Years

Inclusion Criteria7

Age of women < 40years old
Normal uterine cavity as demonstrated by pelvic scanning with or without saline infusion sonogram or hysteroscopy
Regular ovulatory cycles
They will be divided into three groups:
RIF patients (n=35)- those who have failed to get pregnant after replacing four or more cleavage stage embryos or two or more blastocysts in two consecutive transfers.
RPL patients (n=35)- those who have failed in three pregnancies before 24 weeks of gestation and includes embryonic and fetal losses.
'Infertile group'(n=35)- infertility except RIF and RPL, e.g. those seeking for preimplantation genetic testing, male factor infertility, unexplained infertility.

Exclusion Criteria10

History of any medical condition or medications that may predispose to vitamin D sensitivity, altered vitamin D metabolism and/ or hypercalcemia, including active tuberculosis or current therapy for tuberculosis, sarcoidosis, history of renal/ ureteral stones, parathyroid disease, renal or liver failure or current use of anti-convulsants
Taking vitamin D supplement
Endometrial polyp or fibroid distorting the uterine cavity
Presence of hydrosalpinx not corrected surgically
Refusal to join the study
Discontinuation criteria-
If the woman becomes pregnant during the study
Pelvic inflammatory disease/ uterine perforation after endometrial biopsy
Vitamin D toxicity (hypercalcemia)
Withdrawal by patient