Proton Radiation Therapy for the Treatment of Patients With High Risk Prostate Cancer

This study evaluates the use of proton radiation therapy — a precise form of radiation — for men with high-risk prostate cancer. Proton therapy can target tumors more accurately and may reduce damage to nearby healthy tissue compared to standard radiation. **You may be eligible if:** - You have pathologically confirmed high-risk prostate cancer, defined by a Gleason score of 8 or higher, cancer that has grown into the seminal vesicles (cT3b) or beyond (cT4), a PSA over 20, or cancer that has spread to regional lymph nodes - You have adequate blood counts - You are able to give informed consent **You may NOT be eligible if:** - You have bone metastases or distant lymph node metastases - You have previously had a prostatectomy, cryotherapy, or prior radiation to the prostate area - You have uncontrolled illness such as inflammatory bowel disease, active infection, or severe heart or psychiatric conditions Talk to your doctor to see if this trial is right for you.