HM15136 (Efpegerglucagon) Treatment for 8 Weeks in Subjects Aged ≥2 Years With Congenital Hyperinsulinism (CHI)
A Phase 2, Multiple Ascending Dose, Open-label, Proof-of-concept Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of HM15136 (Efpegerglucagon) Treatment for 8 Weeks in Subjects Aged ≥2 Years With Congenital Hyperinsulinism (CHI)
Hanmi Pharmaceutical Company Limited
16 participants
May 5, 2022
INTERVENTIONAL
Conditions
Summary
This study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of HM15136 when used as add-on therapy in subjects with CHI with persistent hypoglycemia while on standard of care treatment (SoC). HM15136 will be administered once weekly in multiple doses to subjects in multiple age including pediatric to find appropriate exposure-response data.
Eligibility
Inclusion Criteria4
- Male and female subjects aged ≥2 years with CHI with persistent hypoglycemia despite current SoC treatment according to the investigator's evaluation or documentation
- Stable therapy with SoC medications with or without nutritional supplementation
- Previously undergone near-total pancreatectomy or being treated with a nonsurgical approach, having been evaluated as not eligible for pancreatic surgery
- HbA1c <7%
Exclusion Criteria5
- Subjects with type 1 or type 2 diabetes mellitus
- Other reasons for hypoglycemia, including but not limited to drug-induced hyperinsulinemic hypoglycemia, etc
- Treatment of CHI with continuous intravenous glucose or glucagon infusion within 3 months prior to screening
- Subjects with current use of any drugs that are known to interfere with the study drug, glucose metabolism, or study procedures (eg, use of systemic glucocorticoids \[excluding topical, intra-articular or ophthalmic application, nasal spray, or inhaled forms\] or insulin)
- Have conditions that could affect glucose levels such as pheochromocytoma, insulinoma, and glucagonoma
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Low dose of HM15136/ High dose of HM15136, SC injection, weekly
Locations(7)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04732416