RecruitingEarly Phase 1NCT04740580

Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease


Sponsor

Baylor College of Medicine

Enrollment

52 participants

Start Date

Feb 15, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Alzheimer's disease (AD) is associated with significant, progressive cognitive decline. Key defects in mitochondrial fuel metabolism insulin resistance, inflammation and decreased brain glucose uptake are linked to AD. This trial will investigate the effects of supplementing glycine and N-acetylcysteine vs. alanine as placebo on these defects in AD, and examine the effects on cognition.


Eligibility

Min Age: 55 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study investigates whether low levels of glutathione (a natural antioxidant in the brain) are linked to the inflammation and memory problems seen in Alzheimer's disease, using specialized brain scans and other tests. **You may be eligible if...** - You are between 55 and 85 years old - You have been experiencing gradual memory decline for more than 1 year, with a cognitive score in the mild-to-moderate range - A PET scan has confirmed amyloid plaques in your brain (a hallmark of Alzheimer's) - You have a study partner (e.g., a family member or close friend) who can participate **You may NOT be eligible if...** - You were hospitalized in the past 3 months - You use insulin or have untreated thyroid disease - You have significant kidney, liver, or blood problems - You have a history of stroke, brain tumor, or active psychiatric conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTGlycine

The active arm will supplement a combination of glycine and N-acetylcysteine (GlyNAC)

DIETARY_SUPPLEMENTN-acetylcysteine

The active arm will supplement a combination of glycine and N-acetylcysteine (GlyNAC)

DIETARY_SUPPLEMENTAlanine

The placebo arm will supplement Alanine


Locations(1)

Baylor College of Medicine

Houston, Texas, United States

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NCT04740580


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