Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

This study is collecting bile samples from patients with primary sclerosing cholangitis (PSC) — a chronic liver disease that damages bile ducts — and from people without PSC, to grow specialized tissue cultures called organoids that may help researchers study the disease in the lab. **You may be eligible if...** - You are between 18 and 85 years old - You have been diagnosed with PSC, OR you are a patient without PSC undergoing a bile duct procedure (as a comparison group) - If you have PSC, you meet standard diagnostic criteria including imaging and lab findings **You may NOT be eligible if...** - You are outside the age range - You do not consent to participate Talk to your doctor to see if this trial is right for you.