RecruitingNCT04753996

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

Sponsor

Mayo Clinic

Enrollment

300 participants

Start Date

Mar 8, 2021

Study Type

OBSERVATIONAL

Conditions

Cholangiocarcinoma Primary Sclerosing Cholangitis PSC

Summary

The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Inclusion Criteria6

PSC
Patients diagnosed with PSC between the age of 18 and 85.
The diagnosis of PSC will be based on standard PSC criteria including clinical and biochemical evidence of chronic cholestasis of at least six months duration, positive cholangiographic findings and compatible liver biopsies if available.
Women with PSC of childbearing potential and pregnant women will be offered enrollment because there is no risk to an unborn child in this investigation. Patients with PSC and Cholangiocarcinoma will be included.
Controls
• Controls without history of PSC or evidence of other chronic liver disease of either gender that will participate in this study should be between the ages of 18-85.