RecruitingPhase 1Phase 2NCT04776330

a Clinical Research of BCMA-Targeted Prime CAR-T Cell Therapy in Relapsed/Refractory Multiple Myeloma and Plasma Cell Disease

Study Evaluating Safety and Efficacy of BCMA-Targeted Prime CAR-T Cell in Patients With Relapsed/Refractory Multiple Myeloma and Plasma Cell Disease


Sponsor

Chongqing Precision Biotech Co., Ltd

Enrollment

80 participants

Start Date

Mar 7, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single arm study to evaluate the efficacy and safety of BCMA-targeted prime CAR-T cells therapy for patients with relapsed/refractory Multiple Myeloma.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests a CAR-T cell therapy (a treatment where your own immune cells are reprogrammed to attack cancer) for people with multiple myeloma (a plasma cell cancer) or related plasma cell diseases that have returned or are no longer responding to treatment. The therapy targets a protein called BCMA found on myeloma cells. **You may be eligible if...** - You are 18–75 years old with relapsed or refractory multiple myeloma or another plasma cell disease - Your cancer has stopped responding to standard chemotherapy, has relapsed after a bone marrow transplant, or is considered high-risk - Your tumor cells express the BCMA protein - Your heart, liver, lungs, and kidneys are functioning adequately - Your expected survival is more than 3 months **You may NOT be eligible if...** - You have serious mental health disorders - Your heart pumping function (ejection fraction) is below 50% - You have severe organ failure - You have active serious infections Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALBCMA targeted prime CAR-T cells

BCMA targeted prime CAR-T cell therapy


Locations(1)

920th Hospital of Joint Logistics Support Force

Kunming, Yunnan, China

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NCT04776330


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