Neuromodulation in the Elderly Depressed: a Brain Imaging Pilot Study

This brain imaging pilot study looks at how a type of brain stimulation — called TMS (transcranial magnetic stimulation) or another neuromodulation method — affects older adults (65+) with treatment-resistant depression. Brain scans before and after treatment will help researchers understand why some people respond better than others. **You may be eligible if...** - You are 65 or older, whether treated in a hospital or as an outpatient - You have been diagnosed with unipolar depression and have a moderately high depression score on a standard rating scale - You have tried at least one antidepressant medication that didn't fully work - You are willing to continue your current antidepressant at a stable dose during the study **You may NOT be eligible if...** - You have psychosis (other than depression-related) - You have a metal implant in your head or a pacemaker (which would make brain stimulation unsafe) - You have epilepsy or a seizure disorder - You are at high risk of suicide Talk to your doctor to see if this trial is right for you.