RecruitingPhase 4NCT04789057

Atorvastatin Effect on Reduction of COPD Exacerbations

Non-commercial Clinical Trial of Statins CAncer Preventive and Pleiotropic TherApy IN Smokers With Chronic Obstructive Pulmonary Disease (COPD)


Sponsor

Medical University of Bialystok

Enrollment

460 participants

Start Date

Feb 11, 2022

Study Type

INTERVENTIONAL

Summary

It is a randomized, multicenter, prospective, double-blind, placebo controlled, interventional clinical trial that will be conducted in Poland, in about 12 Hospital Pulmonary Departments to evaluate the effectiveness of atorvastatin on the reduction of inflammation process in patients with chronic obstructive pulmonary diseases, and possible biomarkers for personalized treatment of COPD.


Eligibility

Min Age: 40 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing whether atorvastatin (a common cholesterol-lowering drug) can reduce flare-ups of chronic obstructive pulmonary disease (COPD) — a lung condition that causes breathing difficulties. Earlier research suggested statins may have anti-inflammatory effects in the lungs, and this study aims to find out whether that translates into fewer COPD episodes. **You may be eligible if...** - You are 40 years or older - You have a confirmed diagnosis of stable COPD with persistent breathing limitation - You have had at least two COPD exacerbations (flare-ups) in the past year - You are able to follow the study protocol and attend visits **You may NOT be eligible if...** - You are already taking a statin medication - Your COPD is currently unstable or you are in the middle of a flare-up - You have liver or muscle conditions that make statin use unsafe - You are under 40 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAtorvastatin 40 Mg Oral Tablet

p.o., once daily

DRUGPlacebo

p.o., once daily


Locations(1)

Medical University Hospital

Bialystok, Poland

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NCT04789057