Targeting ATR in Soft-tissue Sarcomas

This study is testing a drug that targets a cellular stress response pathway (ATR inhibitor) in people with leiomyosarcoma — a rare soft-tissue cancer — that has spread or cannot be surgically removed and has continued to grow despite prior treatment. **You may be eligible if...** - You have been diagnosed with leiomyosarcoma (confirmed by biopsy) - Your cancer has spread or is locally advanced and cannot be removed by surgery - Your cancer has continued to grow during previous treatment - You are 18 or older, in reasonably good health (ECOG ≤ 1) - You have received no more than 3 prior lines of treatment for advanced disease - Your expected survival is more than 3 months **You may NOT be eligible if...** - You have had more than 3 prior lines of treatment - You are a candidate for surgery with curative intent - You have severe organ damage Talk to your doctor to see if this trial is right for you.