RecruitingNCT04812912

Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer

The Effects of Chemotherapy or Radiotherapy on Reproductive and Sexual Health of Early Onset Colorectal Cancer Patients

Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

120 participants

Start Date

Mar 18, 2021

Study Type

OBSERVATIONAL

Conditions

Colorectal, Cancer Colorectal Carcinoma Colorectal Neoplasms

Summary

The purpose of this study is to find out how cancer treatments (chemotherapy and/or radiation therapy) affect reproductive and sexual health in people with early onset colorectal cancer. The study researchers will observe and track changes in hormone levels and in sexual and reproductive health in people with early onset colorectal cancer. This information will help researchers know more about how cancer treatments affect reproductive and sexual health, including the ability to have children (fertility).

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how colorectal cancer and its treatment affect sexual and reproductive health in younger adults — including fertility, sexual function, and relationships — with the goal of better supporting young patients through treatment and survivorship. **You may be eligible if...** - You are a woman aged 18-40 (premenopausal) or a man aged 18-50 at time of diagnosis - You have been diagnosed with colorectal adenocarcinoma (colon or rectal cancer confirmed by biopsy) - You are eligible for curative surgery with or without chemotherapy or radiation - You are willing to complete questionnaires about reproductive and sexual health **You may NOT be eligible if...** - You have already completed all planned treatment - You are outside the specified age ranges - You are unable or unwilling to complete the study questionnaires Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTHormone biomarker analysis

For female patients, hormone biomarker analysis will be performed to measure: anti-Mullerian hormone (AMH), estradiol and FSH in the blood. In male patients, hormone biomarkers of testicular function and spermatogenesis will be monitored: testosterone, inhibin B, steroid hormone binding globulin (SHBG) and FSH. Sperm analysis will also be performed in male patients to monitor changes in sperm count.

BEHAVIORALQoL Questionnaires

All participants will respond to protocol questionnaires, which will include both validated questionnaires as well as non-validated ones. This design will allow for basic demographic, psychosocial and sexual-health-related data to be obtained.