A Study on the Anti-Wrinkle Efficacy Assessment and Safety Evaluation of the Cluster of Autologous Dermal Fibroblast on Bilateral Crow's Feet

This South Korean study tests whether an injection of a cluster of the patient's own skin cells (autologous dermal fibroblasts) into the skin around the eyes can reduce crow's feet wrinkles. Fibroblasts are skin cells that produce collagen, and researchers believe that injecting them where collagen has diminished over time may restore a more youthful appearance. Participants will have a small skin sample taken from an inconspicuous area of the body, and their fibroblasts will be grown in a laboratory before being injected. The study compares this treatment to a placebo injection to see whether the results are genuinely due to the cells. You may be eligible if: - You are 19 years of age or older - You have moderate to severe crow's feet wrinkles on both sides of your face - You have healthy skin at the tissue harvest site - Your blood counts and overall health meet the study requirements You may NOT be eligible if: - You are pregnant, breastfeeding, or planning to conceive within 6 months - You have an autoimmune disease (e.g., lupus, rheumatoid arthritis) - You have a history of severe cardiac, liver, or kidney disease - You have had a tumor or cancer within the past 5 years - You have received systemic corticosteroids in the past 12 weeks - You have had prior autologous fibroblast therapy Talk to your doctor to see if this trial is right for you.