RecruitingNot ApplicableNCT04824105

Modulating Anxious Coping

Modeling and Modulating Mechanisms of Escape, Avoidance, and Approach in the Anxiety Disorder Spectrum


Sponsor

Medical University of South Carolina

Enrollment

80 participants

Start Date

Jun 26, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This is a study to find out if a device that temporarily alters brain activity (repetitive transcranial magnetic stimulation, rTMS) might be used to change how people with anxiety or related concerns cope with feared or anxiety-producing situations. The study is recruiting people who recently started treatment for anxiety or a related concern. The study involves 3 visits to the Medical University of South Carolina. At the first visit, participants do interviews and surveys asking about anxiety and related concerns, and they also do tasks where they see and react to emotional pictures while their brain activation is measured. At the next two visits, participants receive rTMS, which works by rapidly turning a focused magnetic field on and off repeatedly over the head in a way that passes directly through the hair, scalp, and skull and onto the brain and can temporarily increase brain activity under the magnetic field. After rTMS, participants do two tasks where they see and react to emotional situations while wearing sensors on their hand, arms, face, and head. Each visit in this study is expected to last between 2 - 4 hours. This is not a treatment study, but the study is being conducted with the hope that it will help improve treatment in the future.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how people cope with anxiety, and whether certain coping styles can be measured using brain activity. Researchers will use a non-invasive brain recording method (called TMS-EEG) to understand what happens in the brain when people use certain mental strategies to handle anxious thoughts. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with an anxiety disorder (such as generalized anxiety, panic disorder, social anxiety, PTSD, OCD, or adjustment disorder with anxiety) - You are currently seeking or receiving mental health treatment - English is your first or main language **You may NOT be eligible if...** - You have a moderate or severe alcohol or substance use disorder - You have a history of psychosis or bipolar mania - You have epilepsy or another neurological condition that affects brain stimulation safety - You have metal implants in your head or skull defects Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICERepetitive Transcranial Magnetic Stimulation (rTMS)

A repetitive Transcranial Magnetic Stimulation (rTMS) MagVenture MagPro TMS System will be used to deliver intermittent theta burst to ventromedial prefrontal cortex, and continuous theta burst to pre-supplementary motor area.


Locations(1)

Medical University of South Carolina

Charleston, South Carolina, United States

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NCT04824105


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