Sustained Oral Fiber Supplementation for Patients Undergoing Donor Stem Cell Transplantation for Hematological Malignancies
Feasibility of Implementing Sustained Oral Fiber Supplementation for Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Hematological Malignancies
Fred Hutchinson Cancer Center
30 participants
Jun 22, 2022
INTERVENTIONAL
Conditions
Summary
This clinical trial examines sustained oral fiber supplementation for patients undergoing donor stem cell transplantation for hematological malignancies. Patients undergoing donor stem cell transplantation often develop oral and gastrointestinal damage from chemotherapy, radiotherapy, or graft-versus-host disease. Oral fiber nutrition support may improve overall nutrition, support a normal gut microbiome (bacteria that live in the gut) and/or improve gut function in patients undergoing stem cell transplants.
Eligibility
Inclusion Criteria3
- Able to provide written informed consent prior to initiation of any study procedures
- Planned allogeneic stem cell transplantation
- At least 18 years of age
Exclusion Criteria2
- Major psychiatric diagnosis that impairs cognitive functioning or is not controlled at the time of the approach, as judged by the patient's medical team
- Pregnant or breastfeeding. Pregnancy test is obtained as part of pre-transplant evaluation in women of child-bearing potential at arrival to transplant and again within 7 days of conditioning and will be confirmed as negative by review of the chart
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Interventions
Given enteral nutrition via nasoenteric feeding
Given standard of care, which may be parenteral nutrition
Ancillary studies
Receive fiber supplementation orally or enterally
Undergo collection of blood and stool samples
Ancillary studies
Ancillary studies
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04829136