Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy

This study is comparing two strategies for people with limited-stage small cell lung cancer (SCLC) who achieved remission after chemotherapy and radiation: preventive brain radiation (called prophylactic cranial irradiation or PCI) versus regular MRI brain scans to watch for any spread. The question is whether regular monitoring can replace preventive radiation, which can have mental side effects. **You may be eligible if...** - You have limited-stage small cell lung cancer confirmed by pathology or cytology - Your cancer responded to first-line chemotherapy and radiation (complete or partial response) - You had a brain MRI within the last 4 weeks showing no cancer in the brain - You are in reasonably good health (ECOG score 0–2) - Your last treatment cycle ended no more than 8 weeks before enrolling - Your expected survival is at least 12 weeks **You may NOT be eligible if...** - Cancer has been found in your brain - Your cancer did not respond to initial treatment - You are too unwell to tolerate the study procedures Talk to your doctor to see if this trial is right for you.