RecruitingPhase 4NCT04831398

The Effects of Acute Melatonin Supplementation on Cardiovascular Responses to Sympathetic Activation

Sponsor

University of Oklahoma

Enrollment

100 participants

Start Date

Jan 1, 2023

Study Type

INTERVENTIONAL

Conditions

Healthy

Summary

the purpose of this experiment is to determine if acute melatonin supplementation alters central and peripheral cardiovascular responses to a cold pressor test at rest and during dynamic exercise.

Eligibility

Min Age: 18 YearsMax Age: 35 Years

Inclusion Criteria2

Healthy men and women
Women must be premenopausal with a regular menstrual cycle (26-30 days)

Exclusion Criteria11

History of autonomic dysfunction
Cardiovascular diseases
Diabetes
Tobacco/nicotine use
Systolic Pressure >= 130 mmHg
Diastolic Pressure >= 85 mmHg
Regular melatonin use >= 1 use/week
Allergy to melatonin
Cardiometabolic medication use (e.g. anti-hypertensives, insulin-sensitizing, statins)
Sex hormone replacement medical use (e.g. testosterone, estrogen, progesterone)
Pregnancy

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Interventions

DIETARY_SUPPLEMENTmelatonin

A 5mg dose of melatonin spay will be delivered sublingually.

OTHERPlacebo

10 sprays of diluted mint extract. This mimics the sensation and taste of the melatonin spray

Locations(1)

Department of Health and Exercise Science

Norman, Oklahoma, United States

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NCT04831398

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