Randomized Comparison Between Sentinel Lymph Node Biopsy and Lymph Node Dissection in Early Stage Endometrial Cancer

This study is comparing two approaches to lymph node removal during surgery for early-stage uterine cancer — a full lymph node dissection versus a targeted technique (sentinel lymph node biopsy) that identifies only the first lymph nodes where cancer would likely spread — to see if the less invasive approach is just as effective. **You may be eligible if:** - You are a woman between 20 and 80 years old - You have been newly diagnosed with uterine (endometrial) cancer confirmed by biopsy - Your cancer is presumed to be early-stage (stage I or II) - You are scheduled for laparoscopic or robotic hysterectomy - Your lymph nodes appear normal or only mildly enlarged on MRI - Your overall health and blood counts are adequate **You may NOT be eligible if:** - Your cancer has spread beyond the uterus (presumed stage III–IV) - You have had prior radiation or chemotherapy to the pelvis or abdomen - You have lymphedema or prior lymph node surgery in the area - You are pregnant or breastfeeding - You have an allergy to indocyanine green (a dye used in surgery) Talk to your doctor to see if this trial is right for you.