Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy
Effect of Protocol-based Management on Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy: a Pragmatic Interventional Study
Peking University First Hospital
526 participants
Apr 21, 2021
INTERVENTIONAL
Conditions
Summary
The purpose of this pragmatic interventional study is to evaluate whether a protocol-based management of antithrombotic drugs can reduce a composite of perioperative outcomes in patients with chronic antithrombotic therapy before surgery.
Eligibility
Inclusion Criteria4
- \. Patients with continuing antithrombotic therapy (including antiplatelet and/or anticoagulant therapies) for cardiovascular and cerebrovascular diseases for more than 2 weeks.
- \. Patients who have one or more of the following situations: (1) non-valvular atrial fibrillation with a CHA2DS2-VASc score >4; (2) post-artificial valve replacement (including mitral valve, ball-cage valve or tilting disc aortic valve); (3) venous thromboembolism occurred within 1 year, or venous thromboembolism with other high-risk factors which require long-term anticoagulation treatment; (4) coronary heart disease with coronary stent implantation, thrombolytic therapy or other coronary procedures within 2 years, or who had undergone coronary artery bypass grafting within 1 year, or who experienced myocardial infarction or acute coronary syndrome within 1 year; (5) a history of stroke/transient ischemic accident within 1 year, or a history of cervical or intracranial revascularization treatment within 1 year; (6) peripheral arterial disease.
- \. Patients who are scheduled to undergo intra-abdominal surgery (including general and urologic surgery).
- \. Patients who sign written informed consents.
Exclusion Criteria4
- \. Refuse to participate.
- \. Emergency surgery.
- \. Unable to complete the preoperative assessment and follow-up plan.
- \. Other reasons that are considered unsuitable for study participation by the investigators or the attending doctors.
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Interventions
Perioperative antithrombotic therapy is managed according to the latest expert consensus published in the Chinese Medical Journal, 2020.
Perioperative antithrombotic therapy is managed according to current routine practice.
Locations(1)
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NCT04852406