RecruitingPhase 2NCT04858009

Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal Metastasis

A Phase II Study of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Patients With Pancreatic Cancer and Peritoneal Metastasis

Sponsor

Mayo Clinic

Enrollment

40 participants

Start Date

Feb 15, 2024

Study Type

INTERVENTIONAL

Conditions

Metastatic Pancreatic Carcinoma Stage IV Pancreatic Cancer AJCC v8 Metastatic Malignant Neoplasm in the Peritoneum

Summary

This phase II trial studies the effects of hyperthermic intraperitoneal chemotherapy (HIPEC) in treating patients with pancreatic cancer that has spread to the internal abdominal area (peritoneal metastasis). Chemotherapy drugs, such as nab-paclitaxel and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. HIPEC involves "heated" chemotherapy that is placed directly in the abdomen through laparoscopic instruments, instead of through an intravenous injection. This study may help doctors determine how safe and effective HIPEC work in treating patient with pancreatic cancer.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a treatment called HIPEC (heated chemotherapy delivered directly into the abdomen during surgery) in people with pancreatic cancer that has spread to the lining of the abdomen (the peritoneum). **You may be eligible if...** - You are between 18 and 80 years old - You have been diagnosed with pancreatic adenocarcinoma confirmed by biopsy - Your cancer has spread to or is suspected to involve the peritoneum (lining of the abdominal cavity) - Your blood counts and organ function are within acceptable ranges **You may NOT be eligible if...** - Your cancer has spread widely to many distant organs - Your overall health is too poor to tolerate major surgery - You have significantly impaired kidney function Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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