RecruitingNot ApplicableNCT04870255

Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS

Modulating Probabilities: Prediction, Assessment, and Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS

Sponsor

Stanford University

Enrollment

45 participants

Start Date

Jul 20, 2021

Study Type

INTERVENTIONAL

Conditions

Borderline Personality Disorder Depressive Disorder, Major

Summary

This study evaluates the antidepressant effects of an accelerated schedule of theta-burst stimulation, termed accelerated intermittent theta-burst stimulation (aiTBS), in individuals with borderline personality disorder (BPD) or trait and comorbid mood depressive disorder (MDD) or bipolar II disorder in a current mood depressive episode (MDE).

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Dorsomedial Prefrontal Cortex (DMPFC), a medical device called Left Dorsolateral Prefrontal Cortex (L-DLPFC), and others for people with borderline personality disorder and depressive disorder, major. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICELeft Dorsolateral Prefrontal Cortex (L-DLPFC)

Participants who are randomly assigned to this group will receive active iTBS (intermittent theta burst stimulation) to the left DLPFC. Stimulation intensity will be standardized at 90% of resting motor threshold (adjusted for cortical depth). Stimulation will be delivered using the Magventure Magpro X100 TMS system.

DEVICEDorsomedial Prefrontal Cortex (DMPFC)

Participants who are randomly assigned to this group will receive active iTBS (intermittent theta burst stimulation) to the DMPFC. Stimulation intensity will be standardized at 100% of resting motor threshold (adjusted for cortical depth). Stimulation will be delivered using the Magventure Magpro X100 TMS system.

DEVICESham Stimulation

Participants who are randomly assigned to this group will receive sham stimulation to the left DLPFC. Sham stimulation will be delivered using the Magventure Magpro X100 TMS system.