Treatment to Regress to Normoglycemia in Women with a Recent History of GDM

This study is testing whether semaglutide 1 mg (Ozempic), a weekly injectable medication, can help women who had gestational diabetes during pregnancy return to normal blood sugar levels in the months after delivery. Women with gestational diabetes have an elevated risk — up to 70% — of developing type 2 diabetes later in life, and this study aims to find an effective medication to reduce that risk during the postpartum period. Women aged 18 to 45 who had gestational diabetes in their most recent pregnancy, are 6 months to 10 years postpartum, have a BMI of 25 or higher, and show early signs of blood sugar problems (but not yet full diabetes) are eligible — those who are pregnant, breastfeeding, or have significant health conditions are excluded. Participation involves weekly semaglutide or placebo injections for the study duration, with glucose testing and regular clinic visits. This summary was prepared with AI assistance to help patients understand the study in plain language.