RecruitingNot ApplicableNCT04874441

Candida PCR Diagnosis Strategy in Patients From Intensive Care Units

Evaluation of the Effect of the Implementation of a Candida PCR Diagnosis Strategy on the Time Required to Obtain Results in Patients From Intensive Care Units With Suspected Systemic Invasive Candidiasis: Pilot Study

Sponsor

University Hospital, Toulouse

Enrollment

120 participants

Start Date

May 19, 2022

Study Type

INTERVENTIONAL

Conditions

Candida

Summary

The aim of this study is to evaluate the implementation of a new technique for invasive candidiasis diagnosis by PCR. The main objective will be to evaluate the effect of this strategy on the time required to obtain results in patients from intensive care units with suspected systemic invasive candidiasis. This PCR method could allow an antifungal switch to be made earlier, limiting the appearance of resistance and reducing the cost of antifungals for healthcare facilities.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a PCR-based blood test (a highly sensitive DNA detection method) to diagnose Candida (fungal) infections in critically ill patients in the intensive care unit. The goal is to see if this faster, more accurate diagnostic test can improve treatment decisions compared to traditional blood cultures. **You may be eligible if...** - You are a patient in the Toulouse University Hospital intensive care unit - You are not neutropenic (your white blood cell count is not severely depleted) - Your doctor suspects you have an invasive Candida (fungal) infection - A blood culture has been taken and empirical antifungal treatment has been started - You (or your trusted representative) have given informed consent **You may NOT be eligible if...** - You are under legal guardianship or court protection - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTDiagnosis strategy based on C. glabrata / krusei PCR

For diagnosis, a blood cultures and blood tubes for PCR will be collected and patients will be treated with echinocandins in the first instance with an early switch to fluconazole if the C. glabrata / krusei PCR is negative

Locations(1)

Uh Toulouse

Toulouse, Occitanie, France

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT04874441

Related Trials

Rezafungin Peritoneal Diffusion for Intra-abdominal Candidiasis

NCT070932031 location