Candida PCR Diagnosis Strategy in Patients From Intensive Care Units
Evaluation of the Effect of the Implementation of a Candida PCR Diagnosis Strategy on the Time Required to Obtain Results in Patients From Intensive Care Units With Suspected Systemic Invasive Candidiasis: Pilot Study
University Hospital, Toulouse
120 participants
May 19, 2022
INTERVENTIONAL
Conditions
Summary
The aim of this study is to evaluate the implementation of a new technique for invasive candidiasis diagnosis by PCR. The main objective will be to evaluate the effect of this strategy on the time required to obtain results in patients from intensive care units with suspected systemic invasive candidiasis. This PCR method could allow an antifungal switch to be made earlier, limiting the appearance of resistance and reducing the cost of antifungals for healthcare facilities.
Eligibility
Inclusion Criteria4
- Patient affiliated or benefiting from a social protection system
- Patient (or his/her trusted person) having given free and informed written consent to the investigating physician
- Non-neutropenic patient hospitalised in the Toulouse University Hospital intensive care unit.
- Patient with suspected invasive candidiasis for whom a blood culture for fungal infection diagnosis was taken and for whom an empirical treatment with echinocandin at an adapted dose was implemented.
Exclusion Criteria2
- Patients under guardianship or trusteeship, persons under court protection
- Pregnant or breastfeeding patients.
Interventions
For diagnosis, a blood cultures and blood tubes for PCR will be collected and patients will be treated with echinocandins in the first instance with an early switch to fluconazole if the C. glabrata / krusei PCR is negative
Locations(1)
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NCT04874441