RecruitingPhase 2NCT04881682

Immunoadsorption Versus Immunoglobulins for Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)


Sponsor

University of Ulm

Enrollment

20 participants

Start Date

May 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This is a randomized controlled study evaluating safety and efficacy of repeated immunoadsorption versus immunoglobulins in steroid-refractory Chronic Inflammatory Demyelinating Polyneuropathy (CIDP).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two treatments for CIDP (Chronic Inflammatory Demyelinating Polyneuropathy) — a condition where the immune system attacks the nerves, causing weakness and numbness. The two treatments being compared are immunoadsorption (a process that filters harmful antibodies from the blood) and intravenous immunoglobulins (IVIG, which boosts the immune system in a different way). You may be eligible if: - You are 18 years or older - You have been diagnosed with CIDP (possible, probable, or definite) for 3 years or less - You have already tried corticosteroids (methylprednisolone) and either did not respond well, had significant side effects, or have a reason you cannot take them You may NOT be eligible if: - You have signs of an active serious infection (high CRP or a urinary tract infection) - You have taken an ACE inhibitor within the past week - You have IgA deficiency - You have other contraindications to immunoadsorption or IVIG Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEImmunoadsorption

see arm/group description

BIOLOGICALImmunoglobulins

see arm/group description


Locations(1)

Department of Neurology, University of Ulm

Ulm, Baden-Wurttemberg, Germany

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NCT04881682


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