RecruitingPhase 2NCT04888429

Camrelizumab Plus Famitinib as Treatment in Patient With Advanced or Metastatic Pulmonary Sarcomatoid Carcinoma

Camrelizumab Plus Famitinib as Treatment in Patient With Advanced or Metastatic Pulmonary Sarcomatoid Carcinoma:A Multi-center, Single-arm Study


Sponsor

Qian Chu

Enrollment

28 participants

Start Date

Jul 19, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single arm, multi-center clinical trial. Target population is patients with Advanced or Metastatic Pulmonary Sarcomatoid Carcinoma,aiming to evaluate the efficacy and safety of the combination therapy of Camrelizumab and famitinib . Camrelizumab is a humanized anti-PD1 IgG4 monoclonal antibody, and famitinib is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a combination of two drugs — camrelizumab (an immunotherapy) and famitinib (a targeted therapy) — as a first-line treatment for patients with an aggressive and rare type of lung cancer called pulmonary sarcomatoid carcinoma. **You may be eligible if...** - You have been diagnosed with advanced or metastatic pulmonary sarcomatoid carcinoma (stage IIIB, IIIC, or IV) confirmed by biopsy - You have had no prior systemic treatment for this cancer (prior adjuvant/neoadjuvant therapy that ended 6+ months ago is allowed) - You have at least one measurable tumor - You have a good performance level (ECOG 0-1) - You have a life expectancy of more than 3 months and adequate organ function **You may NOT be eligible if...** - Your tumor has specific gene mutations (EGFR, ALK, ROS1, BRAF, or MET exon 14) that have other targeted therapies available - You have uncontrolled high blood pressure or active bleeding - You have active brain metastases - You have active hepatitis B or HIV - You are pregnant or breastfeeding - You have significant heart disease or abnormal heart rhythms Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCamrelizumab

Patients received camrelizumab 200 mg every 3 weeks

DRUGFamitinib

Patients received Famitinib 20 mg once per day


Locations(8)

The first Affiliated Hospital of Xiamen University

Xiamen, Fujian, China

Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou University

Zhengzhou, Henan, China

Henan Provincial People's Hospital

Zhengzhou, Henan, China

Qian Chu

Wuhan, Hubei, China

Hubei Cancer Hospital

Wuhan, Hubei, China

Renmin Hospital of Wuhan University Hubei General Hospital

Wuhan, Hubei, China

The Second Xiangya Hospital of Central South University

Changsha, Hunan, China

The First Affiliated Hospital of Shandong First Medical University

Jinan, Shandong, China

View Full Details on ClinicalTrials.gov

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NCT04888429