RecruitingNot ApplicableNCT04890171

Comparison of Endoscopic Resection and Surgery for Early Gastric Cancer With Undifferentiated Histological Type

Comparison of Endoscopic Resection and Surgery for Early Gastric Cancer With Undifferentiated Histological Type: a Multicenter Randomized Controlled Trial (ERASE-GC Trial)


Sponsor

National Cancer Center, Korea

Enrollment

708 participants

Start Date

Jun 11, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This multi-center, randomized controlled trial is designed to evaluate clinical effectiveness and cost-effectiveness of ESD for undifferentiated type of EGC meeting the expanded indication compared with surgery.


Eligibility

Min Age: 19 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two treatments for early-stage stomach cancer with a specific cell type (undifferentiated, such as signet ring cell carcinoma): endoscopic submucosal dissection (a non-surgical procedure that removes the tumor through a scope) versus standard stomach surgery. Researchers want to know if the less invasive procedure is just as safe and effective. **You may be eligible if...** - You are between 19 and 75 years old - You have been diagnosed with early undifferentiated gastric cancer (signet ring cell, poorly differentiated, or poorly cohesive type) - Your tumor is confined to the inner lining of the stomach, has no ulcer, and is 2 cm or smaller - Imaging shows no spread to lymph nodes or distant organs - You are willing and able to give consent **You may NOT be eligible if...** - You are under 19 or over 75 years old - You have had another cancer (other than skin cancer in remission) treated within the past 5 years - You have previously had stomach or esophageal surgery - You have multiple stomach cancers - You have serious heart, liver, kidney, or lung conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREEndoscopic submucosal dissection

Endoscopic submucosal dissection by a endoscopist using endoscopic devices

PROCEDURESurgery

Gastrectomy with lymph node dissection by a surgeon


Locations(1)

National Cancer Center, Korea

Goyang-si, Gyeonggi-do, South Korea

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NCT04890171


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