A First-in-human Study of 3H-10000 in Patients With Unresectable or Metastatic Solid Tumors

This is a first-in-human study testing a new cancer drug called 3H-10000 in patients with solid tumors (cancers involving organs or tissues) that cannot be removed by surgery or have spread to other parts of the body. The goal is to determine a safe dose and understand how the drug behaves in the body. **You may be eligible if:** - You are 18 years or older - You have an unresectable or metastatic solid tumor - You have at least one measurable tumor on imaging scans - You have good general health (ECOG performance status 0–1) - Your life expectancy is at least 3 months - You are willing and able to follow the study schedule **You may NOT be eligible if:** - You have cancer that has spread to the membranes lining the brain or spinal cord (carcinomatous meningitis) - You have uncontrolled fluid buildup around your lungs, heart, or abdomen requiring frequent draining - You have received another experimental drug within the past 4 weeks - You have unresolved serious side effects from prior cancer treatment - You have a significant cornea or retina eye condition (eye problems involving the surface of the eye or the retina) Talk to your doctor to see if this trial is right for you.