Salvage Cryotherapy for Recurrent Prostate Cancer After Radiation Therapy

This study is evaluating cryotherapy (freezing the prostate) as a salvage treatment for men whose prostate cancer has come back in the prostate after they previously received radiation therapy or brachytherapy (internal radiation seeds). **You may be eligible if...** - Your prostate cancer has come back locally (confirmed by biopsy) after radiation or brachytherapy - Imaging (PET/PSMA scan) shows no signs of cancer spread to other parts of the body - Your PSA level is below 10 ng/mL - Your prostate volume is under 100 cc - Your expected survival is more than 10 years - Your cancer on MRI is staged no higher than cT3a and does not involve the bladder neck or urethra **You may NOT be eligible if...** - You have confirmed cancer spread to distant areas - You have had major rectal surgery - You have significant problems with the lower urinary tract or rectum - You already have a fistula (abnormal connection) between the urethra, rectum, or bladder Talk to your doctor to see if this trial is right for you.