RecruitingNot ApplicableNCT04903925

Probiotics for Improving Post-surgical Healing

Efficacy of Probiotics in Improving Post-surgical Healing for Impacted Tooth Extractions


Sponsor

University of Pisa

Enrollment

150 participants

Start Date

Apr 13, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

A randomized, double-blind, placebo-controlled clinical trial will be performed to assess the efficacy of a probiotic containing Lactobacillus reuteri in improving post-surgical wound healing after impacted tooth extractions. The Primary aim is to evaluate the efficacy of L. reuteri in improving post-extractive healing. The Secondary aim is to evaluate the efficacy of L. reuteri in association with an antibiotic therapy (amoxicillin) in reducing the incidence and severity of antibiotic-associated gastro-intestinal symptoms.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates whether taking probiotics (beneficial bacteria supplements) after having an impacted tooth (wisdom tooth) extracted can improve healing and reduce complications like infection or dry socket. Probiotic use after oral surgery is a relatively new concept. You may be eligible if: - You are over 18 years old - You need one or more impacted teeth removed - You can understand and sign an informed consent form You may NOT be eligible if: - You have an allergy to penicillin - You take immunosuppressive drugs or have a compromised immune system - You take amino-bisphosphonates or anti-angiogenic medications - You have had radiation to the head or neck area - You have uncontrolled diabetes, kidney failure, drug/alcohol addiction, or psychiatric disorders Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREImpacted tooth extraction

All patients will undergo a surgical tooth extraction


Locations(1)

U.O. Odontostomatologia e Chirurgia del Cavo Orale

Pisa, Italy

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NCT04903925


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