Probiotics for Improving Post-surgical Healing
Efficacy of Probiotics in Improving Post-surgical Healing for Impacted Tooth Extractions
University of Pisa
150 participants
Apr 13, 2021
INTERVENTIONAL
Conditions
Summary
A randomized, double-blind, placebo-controlled clinical trial will be performed to assess the efficacy of a probiotic containing Lactobacillus reuteri in improving post-surgical wound healing after impacted tooth extractions. The Primary aim is to evaluate the efficacy of L. reuteri in improving post-extractive healing. The Secondary aim is to evaluate the efficacy of L. reuteri in association with an antibiotic therapy (amoxicillin) in reducing the incidence and severity of antibiotic-associated gastro-intestinal symptoms.
Eligibility
Inclusion Criteria3
- need for impacted tooth extractions
- over age 18
- ability to understand and to sign an informed consent form
Exclusion Criteria9
- allergy to penicillin
- contraindications to oral surgery
- treatment with immunosuppressive agents or immunocompromised
- treatment with amino-bisphosphonate and anti-angiogenetic medications
- irradiation to head and neck area
- uncontrolled diabetes
- renal failure
- drug and alcohol addiction
- psychiatric disorders
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
All patients will undergo a surgical tooth extraction
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04903925