Contrast-enhanced Spectral Mammography (CESM) Breast Cancer Screening

This study compares a newer type of mammogram called contrast-enhanced spectral mammography (CESM) — which uses contrast dye to highlight unusual areas — to standard mammography for detecting breast cancer in women with dense breast tissue, which can make standard mammograms harder to read. **You may be eligible if...** - You are a woman between 40 and 69 years old - Your last mammogram showed dense breast tissue (heterogeneous or extremely dense) - You had a normal mammogram (BI-RADS 1 or 2) within the past 2 years - You are scheduled for a routine screening mammogram **You may NOT be eligible if...** - You have an allergy to iodine contrast dye - You have kidney disease or kidney function problems - You are pregnant - You have diabetes, asthma, sickle cell anemia, or are on dialysis - You have a history of certain vascular or collagen diseases - You are already classified as high risk for breast cancer (greater than 20% lifetime risk) Talk to your doctor to see if this trial is right for you.