Nebulized Tranexamic Acid in Sinus Surgery
Does Nebulized Tranexamic Acid Affect Operative Field in Sinus Surgery? A Double Blind Randomized Clinical Trial
Assiut University
90 participants
May 6, 2021
INTERVENTIONAL
Conditions
Summary
The results of several recent studies on endoscopic sinus surgery through topical administration of tranexamic acid are encouraging in terms of the efficacy of tranexamic acid for intraoperative bleeding and other pathological conditions.The purpose of this study is to analyze the efficacy of nebulized tranexamic acid to improve the surgeon and patient experiences of sinus surgery and know the effective and safe dose of nebulized tranexamic acid.
Eligibility
Inclusion Criteria2
- Either sexes (age 18-65 years) of ASA I-II who are listed for elective functional endoscopic sinus surgery (FESS) under general anesthesia
- normal accepted coagulation profile and hematocrit value ≥30
Exclusion Criteria10
- chronic renal failure
- liver cirrhosis
- bleeding disorders
- current anticoagulant therapy
- pregnancy or breastfeeding
- impaired color vision
- severe vascular ischemia
- history of venous thrombosis, pulmonary embolism
- long term treatment with acetylsalicylic acid or non-steroidal anti-inflammatory drugs not discontinued before surgery
- hemoglobin (HB) concentration <10 mg/dl _allergy to TXA.
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Interventions
Tranexamic acid nebulization 15 minutes before sinus surgery
Normal saline placebo nebulization 15 minutes before sinus surgery
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04905901