All-extremity Exercise During Breast Cancer Chemotherapy

This study is testing whether an exercise program using both arms and legs during breast cancer chemotherapy can reduce side effects and improve health outcomes compared to standard care. **You may be eligible if:** - You are a woman aged 18–85 with a diagnosis of invasive breast cancer (stages I–III) that has not spread to other organs - You are about to start chemotherapy (with anthracyclines, alkylating agents, or taxanes) - You have no major reasons that would make exercise unsafe **You may NOT be eligible if:** - You are receiving certain targeted therapies (CDK4/6 or PARP inhibitors) - You are getting radiation therapy at the same time as chemotherapy - You already have moderate or severe arm swelling (lymphedema stage 2 or higher) - You have significant heart disease (history of stroke, heart failure, heart attack, or angina) - You are currently in another experimental diet or lifestyle study Talk to your doctor to see if this trial is right for you.