A Single Bolus of Dexmedetomidine Versus Normal Saline in Postoperative Agitation
Optic Nerve Sheath Diameter (ONSD): A New Modality to Assess Postoperative Agitation After a Single Bolus of Dexmedetomidine Versus Normal Saline in Children With Cleft Palate Repair
Assiut University
60 participants
Jun 20, 2021
INTERVENTIONAL
Conditions
Summary
The hypothesis of this study is to investigate and compare the efficacy between the administrations of single intravenous (IV) dose of dexmedetomidine versus normal saline in preventing immediate postoperative agitation in children undergoing cleft palate repair.
Eligibility
Inclusion Criteria2
- Children (age 1-7 years) of American Society of Anaesthesiologists physical status (ASA) I-II
- Elective cleft palate repair ± cleft lip surgery under general anesthesia.
Exclusion Criteria7
- Ventriculo-peritoneal shunt
- Suspected meningitis
- Congenital hydrocephalus
- Clinical signs of suspected increased intracranial pressure
- On treatment for seizures or metabolic diseases
- Children with developmental delay
- Hypersensitivity to dexmedetomidine or nalbuphine
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Interventions
A single dose of 0.5 µ/kg IV dexmedetomidine at the end of surgery
Same volume of saline placebo IV at the end of surgery
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT04928391