The Effect of Micro Fragmented Adipose Tissue (MFAT) on Shoulder Osteoarthritis

This study tests whether injecting micro-fragmented adipose tissue (MFAT) — small pieces of a patient's own fat tissue, processed and injected into the joint — can reduce pain and improve function in people with shoulder osteoarthritis (wear and tear of the shoulder joint). This regenerative medicine approach may provide a non-surgical option for people who have not responded to physical therapy or anti-inflammatory treatments. You may be eligible if: - You are between 25 and 75 years old - You have diagnosed osteoarthritis of the shoulder (glenohumeral joint) - You have tried and failed at least 6 weeks of physical therapy and anti-inflammatory medications - You are able to walk and complete follow-up surveys You may NOT be eligible if: - You have severe (bone-on-bone) or minimal shoulder arthritis on X-ray - You had a prior joint replacement or cartilage regeneration surgery in that shoulder - You had a cortisone, PRP, or hyaluronic acid injection in the past 3 months - You have rheumatoid or inflammatory arthritis - You have uncontrolled diabetes, HIV, hepatitis C, or active infection - Your BMI is over 40 - You are pregnant or planning pregnancy - You have fibromyalgia, chronic opioid use, or chronic multi-site pain - You have a massive rotator cuff tear (2 tendons with retraction) Talk to your doctor to see if this trial is right for you.