Study of RTMS Analgesic Effect in Chronic Neuropathic Pain,
Randomized Double-blind Study of RTMS Analgesic Effect in Chronic Neuropathic Pain. Comparison Between Three Groups: Motor Cortex Stimulation by the Classic Coil B65, Deeper Stimulation by the Coil B70 and Placebo Stimulation. Analysis of Long-term RTMS-induced Brain Changes Using FMRI.
University Hospital, Grenoble
45 participants
Jul 16, 2021
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to compare the analgesic effectiveness of three modes of repetitive Transcranial Magnetic Stimulation (rTMS) in chronic neuropathic pain: * Classical rTMS stimulation * Deeper rTMS stimulation * Sham rTMS stimulation
Eligibility
Inclusion Criteria6
- Patient's written consent
- Affiliated with social security system
- Male or female, suffering for more than a year from unilateral refractory neuropathic pain: hemi-body, upper limb, lower limb and facial chronic pain.
- Patient whose analgesic treatment, is stable for at least 1 month.
- Patient not responding to conventional treatments
- Prescreening EVN >3
Exclusion Criteria8
- History of drug addiction, epilepsy, cranial trauma
- History of psychiatric disorder
- Patients previously treated with rTMS
- Patient with intracranial ferromagnetic material or implanted stimulator
- New treatment for less than one month
- Pregnant or Breastfeeding woman
- Patient who does not understand the study protocol
- Persons who are protected under the act.
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Interventions
The rTMS protocol consist of one session per day for five days during the first week, then three sessions the second week and then one session the third week, followed by two monthly sessions.
Locations(1)
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NCT04936646