RecruitingPhase 3NCT04939935

Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)

Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD): A Randomised Placebo-Controlled Trial

Sponsor

The University of Queensland

Enrollment

1,174 participants

Start Date

Nov 29, 2022

Study Type

INTERVENTIONAL

Conditions

Autosomal Dominant Polycystic Kidney Disease

Summary

This study will investigate if a medication (metformin) widely used in the treatment of diabetes could be re-purposed for the treatment of patients with a diagnosis of early stage ADPKD to slow the rate of kidney function decline, reducing morbidity and mortality and improving the quality of life for ADPKD patients.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Control and a drug called Metformin XR for people with autosomal dominant polycystic kidney disease. The study is currently recruiting participants at 49 locations. People eligible for this study include aged 18 Years to 70 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMetformin XR

Extended release metformin.

OTHERControl

Placebo is inactive tablets that is identical to the intervention Metformin tablets.

Locations(49)

Renal Research

Gosford, New South Wales, Australia

Royal Prince Alfred Hospital

Sydney, New South Wales, Australia

Royal North Shore Hospital

Sydney, New South Wales, Australia

Westmead Hospital - Western Sydney Local Health District

Sydney, New South Wales, Australia

Bundaberg Hospital

Bundaberg, Queensland, Australia

Townsville University Hospital

Douglas, Queensland, Australia

Royal Brisbane and Women's Hospital

Herston, Queensland, Australia

Princess Alexandra Hospital

Woolloongabba, Queensland, Australia

Royal Adelaide Hospital

Adelaide, South Australia, Australia

Royal Melbourne Hospital

Melbourne, Victoria, Australia

Austin Health

Melbourne, Victoria, Australia

Monash Medical Centre

Melbourne, Victoria, Australia

Sir Charles Gairdner Hospital

Perth, Western Australia, Australia

Te Whatu Ora - Hauora a Toi Bay of Plenty

Tauranga, Bay of Plenty, New Zealand

Te Whatu Ora - Te Tai Tokerau

Whangārei, Northland, New Zealand

Te Whatu Ora - Southern

Dunedin, Otago, New Zealand

Te Whatu Ora - Taranaki

New Plymouth, Taranaki Region, New Zealand

Ta Pae Hauora o Ruhahine o Terarua Mid Central

Palmerston North, New Zealand

Royal Devon & Exeter Hospital

Exeter, Devon, United Kingdom

Nottingham Renal Unit, Nottingham City Hospital

Nottingham, East Midlands, United Kingdom

Raigmore Hospital

Inverness, Inverness Shire, United Kingdom

Royal Preston Hospital

Preston, Lancashire, United Kingdom

Salford Royal Hospital

Salford, Lancashire, United Kingdom

Leicester General Hospital

Leicester, Leicestershire, United Kingdom

St Helier Hospital

Carshalton, London, United Kingdom

Aintree University Hospital

Liverpool, Merseyside, United Kingdom

Norfolk and Norwich University Hospital

Norwich, Norfolk, United Kingdom

Antrim Area Hospital

Antrim, Northern Ireland, United Kingdom

Ulster Hospital

Belfast, Northern Ireland, United Kingdom

Altnagelvin Hospital

Londonderry, Northern Ireland, United Kingdom

Daisy Hill Hospital

Newry, Northern Ireland, United Kingdom

Oxford Kidney Unit, Churchill Hospital,

Oxford, Oxfordshire, United Kingdom

Doncaster Royal Infirmary

Doncaster, South Yorkshire, United Kingdom

Sheffield Kidney Institute

Sheffield, South Yorkshire, United Kingdom

Royal Stoke University Hospital

Stoke-on-Trent, Staffordshire, United Kingdom

Freeman Hospital

Newcastle upon Tyne, Tyne and Wear, United Kingdom

Queen Elizabeth Hospital Birmingham

Birmingham, West Midlands, United Kingdom

Bradford Renal Unit, St Luke's Hospital

Bradford, West Yorkshire, United Kingdom

Cardiff and Vale University Health Board

Cardiff, United Kingdom

Epsom and St Helier University Hospitals

Carshalton, United Kingdom

The Royal London Hospital

London, United Kingdom

Royal Free Hospital

London, United Kingdom

King's College Hospital

London, United Kingdom

St George's University Hospital

London, United Kingdom

Nottingham University Hospital

Nottingham, United Kingdom

University Hospitals Plymouth NHS Trust

Plymouth, United Kingdom

East & North Hertfordshire Teaching NHS Trust

Stevenage, United Kingdom

South Tyneside and Sunderland NHS Foundation Trust

Sunderland, United Kingdom

York and Scarborough Teacehing Hospitals

York, United Kingdom

View Full Details on ClinicalTrials.gov

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