RecruitingNot ApplicableNCT04941664

Minimum Effective Local Anesthetic Volume for Ultrasound Guided Superior Trunk Block

Minimum Effective Local Anesthetic Volume of 0.5% Levobupivacaine Required for Ultrasound Guided Superior Trunk Block for Shoulder Surgery

Sponsor

Chinese University of Hong Kong

Enrollment

25 participants

Start Date

Jan 19, 2023

Study Type

INTERVENTIONAL

Conditions

Musculoskeletal Diseases or Conditions

Summary

The objective of this study is to identify the minimum effective dosage of a commonly used local anaesthetic drug "levobupivacaine" required to produce an effective ultrasound guided (USG) superior trunk block (STB) in at least 90% of patients for shoulder arthroscopic surgeries.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria1

American Society of Anesthesiologists (ASA) physical status I-III scheduled to undergo elective upper shoulder arthroscopic rotator cuff repair procedure

Exclusion Criteria6

Patient refusal
pregnancy
skin infection at the site of block placement
history of allergy to local anaesthetic drugs
bleeding tendency or with evidence of coagulopathy
pre-existing neurological deficit or neuromuscular disease.

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Interventions

DRUG0.5% levobupivacaine

This study adopts a "Modified Narayana rule (MNR)", a sequential up-and-down pharmacodynamics method (UDM) to estimate the minimum effective local anesthetic volume of 90% (MELVA90) of cases of the aforementioned local anesthetic (LA), in order to produce the surgical anesthesia of the patients scheduled for shoulder surgeries. Based on the principal investigator's clinical experience, the initial volume of 8ml will be used. Depending on the success or failure of the superior trunk block, which is defined as the readiness for surgery at 30 minutes after the block, the volume for the next patient will be adjusted up or down by 2ml. The upper dose limit of the study to minimize the potential for local anesthetic systemic toxicity will be 16ml and the lower dose limit will be 4ml, which will be of no clinical importance.