Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment

This study is comparing two types of brain stimulation treatments for depression — standard high-frequency transcranial magnetic stimulation (TMS, applied to the surface of the brain) versus deep TMS (which penetrates further into the brain) — to find out which works better or more quickly for people with moderate-to-severe depression. **You may be eligible if...** - You are 18 or older - You have been diagnosed with a major depressive episode (recurrent or isolated) based on standard psychiatric criteria (DSM-IV) - Your depression is at least moderately severe (score of 21 or above on the MADRS scale) - Your antidepressant medication has been stable for at least 3 weeks - You are affiliated with social security in France **You may NOT be eligible if...** - You have psychotic features in your depression - You have schizophrenia or a history of alcohol or substance dependence - You have already had electroconvulsive therapy (ECT) for this episode without improvement - You are hospitalised involuntarily - You have a high suicide risk - You have a pacemaker, metal implants in your head or eyes, a cochlear implant, or other contraindications to MRI or TMS - You are pregnant - You are enrolled in another interventional study Talk to your doctor to see if this trial is right for you.