Clinical Study of CAIX-targeted CAR-T Cells in the Treatment of Advanced Renal Cell Carcinoma

This study is testing a new type of immune cell therapy called CAIX-targeted CAR-T cells — immune cells that have been re-engineered to hunt and destroy kidney cancer cells — in people with advanced kidney cancer that has stopped responding to other treatments. **You may be eligible if...** - You are between 18 and 70 years old - You have advanced or metastatic renal cell carcinoma (kidney cancer) that is no longer responding to treatment - You have already received first-line and second-line targeted therapies - You have also previously received PD-1/PD-L1 immunotherapy (up to 2 regimens) - You have measurable or evaluable tumours on imaging - Your heart, liver, kidneys, and lungs are functioning adequately **You may NOT be eligible if...** - You have not tried prior targeted or immunotherapy treatments - Your organ function is significantly impaired - You have active or uncontrolled infections - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.