Fecal Microbial Transplants for the Treatment of Pancreatic Cancer

This study is testing whether a fecal microbiome transplant (FMT) — transferring gut bacteria from a healthy donor — before surgery can improve the immune environment around a pancreatic tumour and potentially lead to better outcomes after a Whipple procedure (the major surgery used to remove pancreatic cancer). **You may be eligible if...** - You are 18 years or older, male or female - You are a patient at MD Anderson Cancer Center - You have been diagnosed with pancreatic ductal adenocarcinoma (the most common type of pancreatic cancer) and are expected to have a Whipple surgery - Your blood counts, liver, and kidney function are all within acceptable ranges - You are willing and able to sign informed consent and participate in study procedures **You may NOT be eligible if...** - You are not planning to have a Whipple procedure - Your blood counts, liver, or kidney function do not meet the minimum requirements - You are pregnant or breastfeeding - You have serious conditions that make the FMT procedure unsafe Talk to your doctor to see if this trial is right for you.