RecruitingNCT04985318

Retrospective Analysis of the Efficiency of Caplacizumab in the Treatment of aTTP

Retrospective Analysis of the Efficiency of Caplacizumab in the Treatment of Acquired Thrombotic Thrombocytopenic Purpura (aTTP)- REACT-2020


Sponsor

University of Cologne

Enrollment

350 participants

Start Date

Mar 25, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

The objective of this national, prospective, multi-centre observational study is to describe the prescription rational and practice in Germany, confirm the efficacy of caplacizumab in a real-world setting, and identify predicting factors in iTTP-patients with regard to persistent autoimmune activity, therapy guidance and risk of complications. The rational is to develop new treatment algorithms that optimize overall patient outcome and reduce treatment cost.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a retrospective study examining the real-world effectiveness of caplacizumab, a relatively new medication used to treat acquired Thrombotic Thrombocytopenic Purpura (aTTP) — a rare and life-threatening blood disorder where tiny clots form throughout blood vessels. Researchers are reviewing past patient records to assess how well caplacizumab worked in practice. You may be eligible if... - You have a confirmed diagnosis of an acute episode of acquired TTP - You received at least one dose of caplacizumab as part of your treatment - You are 18 years or older and have signed informed consent You may NOT be eligible if... - You have the hereditary (inherited) form of TTP, not the acquired form - You are unable to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCablivi®

Intervention with Cablivi® take place outside of the study


Locations(1)

University Hospital of Cologne

Cologne, Germany

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NCT04985318


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