Scalp Cooling in MBC

This study is testing whether scalp cooling — wearing a special cold cap during chemotherapy — can prevent or reduce hair loss in people with metastatic breast cancer receiving specific chemotherapy regimens. Hair loss is one of the most distressing side effects of chemotherapy. **You may be eligible if...** - You are 18 or older with metastatic invasive breast cancer - You have hair at the start of the study - You are planned to receive one of these chemotherapy regimens for at least 4 cycles: sacituzumab govitecan, trastuzumab deruxtecan, or eribulin - Your general health status is acceptable (ECOG ≤2) **You may NOT be eligible if...** - You have a blood cancer (e.g., leukemia or lymphoma) - You have scalp metastases - You already have hair loss - You have migraine headaches - You have conditions worsened by cold (e.g., cold urticaria or cold agglutinin disease) Talk to your doctor to see if this trial is right for you.